MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202621078532 A) filed by Ansicht Voneden India on June 25, 2026, for Engineered Exosomal Dna Cassette Concoction And Scaffold For Motor Neuron Repair.
Inventor includes Dr. Ajinkya Inamdar.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: ABSTRACT ENGINEERED EXOSOMAL DNA CASSETTE CONCOCTION AND SCAFFOLD FOR MOTOR NEURON REPAIR The instant disclosure provides a concoction of 49 engineered synthetic DNA cassettes (SEQ ID NOs: 1 to 49) for motor-neuron repair, classified into cytoprotective and oxidative-stress, immune- modulation, pathology-driver silencing, restoration, partial-reprogramming, neurotrophic-ligand, growth-oriented-receptor, guidance, pathway-antagonist and molecular-movement modules, the cargo of which is loaded into or displayed upon engineered extracellular vesicles by a multi-pathway sorting-motif architecture. The integrating lentiviral cassettes are deployable integratively or non-integratively. Reversible dCas9-KRAB repressors silence superoxide dismutase-1, C9orf72 and FUS; an adenosine-deaminase RNA-editing enzyme, stathmin-2 and a kinesin motor domain (SEQ ID NO: 49) restore editing and axonal transport; a partial-reprogramming module is delivered through a prolyl-endopeptidase and thimet-oligopeptidase cleavable linker; and each neurotrophic ligand is co-presented with its cognate receptor. The instant disclosure further provides an electrically semi-conductive hydrogel micro-thread scaffold article incorporating the engineered extracellular-vesicle population along a bilateral exponential spatial gradient and a temporally gated delayed-release sequence, and methods of manufacture thereof. (
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