MUMBAI, India, Aug. 12 -- Intellectual Property India has published a patent application (202621076090 A) filed by Ansicht Voneden India on June 19, 2026, for Engineered Exosomal Dna Cassettes And Scaffold For Nigrostriatal Dopaminergic Neuron Repair.
Inventor includes Dr. Ajinkya Inamdar.
The application for the patent was published on August 07, 2026, under issue no. 32/2026.
Abstract: The instant disclosure provides a concoction of 53 engineered synthetic DNA cassettes (SEQ ID NOs: 1 to 53) for nigrostriatal dopaminergic neuron repair, classified into cytoprotective and oxidative-stress, immune-modulation, pathology-driver silencing, dopaminergic-specification, dopamine-biosynthesis, partial-reprogramming, neurotrophic-ligand, growth-oriented-receptor, guidance, pathway-antagonist and molecular-movement modules, cargo of which is loaded into or displayed upon engineered extracellular vesicles by a multi-pathway sorting-motif architecture. Reversible dCas9-KRAB repressors lower leucine-rich repeat kinase-2 and alpha- synuclein; FOXA2, LMX1A, NR4A2 and PITX3 respecify dopaminergic identity; GTP cyclohydrolase-1, tyrosine hydroxylase and DOPA decarboxylase restore dopamine biosynthesis; superoxide dismutase-2 and BCL-2 provide mitochondrial support; a kinesin motor domain (SEQ ID NO: 53) restores axonal transport; and each neurotrophic ligand is co-presented with its cognate receptor. The instant disclosure further provides an electrically semi-conductive hydrogel micro-thread scaffold article incorporating the engineered extracellular-vesicle population along a bilateral exponential spatial gradient and a temporally gated delayed-release sequence, and methods of manufacture thereof.
Disclaimer: Curated by HT Syndication.
