MUMBAI, India, June 24 -- Intellectual Property India has published a patent application (202617062918 A) filed by Robert Bosch Gmbh on May 18, 2026, for Enzyme Translocators In Nanogap With 3'-Esters.
Inventors include Vukasin, Gabrielle; Johnson, Christopher; Bhadran, Abhi; Yama, Gary; Darvish, Armin; Lang, Christoph; Grumaz, Christian; Pilsl, Sebastian; Fomina, Nadezda; and Shin, Young Shik.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: A method for nucleic acid sequencing includes providing at least one device comprising a first electrode and a second electrode separated by a dielectric layer, and a polymerase enzyme attached to the surface of the dielectric layer. The dielectric layer induces an electroactive molecule to interact with the electrodes to complete an electrical circuit. The polymerase enzyme targets a polynucleotide strand to the dielectric layer. A sample including a polynucleotide strand and modified nucleotides having an electroactive label covalently bound to the 3'-OH of a sugar ring of the nucleotide via an ester group is provided to the at least one device. Potentials are applied to each electrode to induce electron flow between the electrodes to produce a measurable electrical signal when an electroactive label is present in the dielectric layer. Electrical signals from the electrodes are detected to determine when a modified nucleotide is present in the dielectric layer.
Disclaimer: Curated by HT Syndication.
