MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202521040212 A) filed by Mehul P. Parmar; Disha P. Vala; Hitendra M. Patel; Shreya Kashyap; and Sourav Banerjee on April 25, 2025, for Ethanol-Mediated One-Pot Synthesis Of 3-Phenyl-3,4,5,12-Tetrahydrobenzo[4,5]imidazo[2,1-B]quinazolin-1(2h)-Ones As Pdgfra Inhibitors.
Inventors include Mehul P. Parmar; Disha P. Vala; Hitendra M. Patel; Shreya Kashyap; and Sourav Banerjee.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: Title: “Ethanol-Mediated One-Pot Synthesis of 3-Phenyl-3,4,5,12-tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolin-1(2H)-ones as PDGFRA Inhibitors” ABSTRACT: The present invention relates to an ethanol-mediated one-pot synthetic methodology for the preparation of novel 3-phenyl-3,4,5,12-tetrahydrobenzo[4,5]imidazo[2,1- b]quinazolin-1(2H)-one derivatives. The synthesized compounds exhibit potent inhibitory activity against platelet-derived growth factor receptor alpha (PDGFRA), a member of the type III receptor tyrosine kinase family, which is implicated in the pathogenesis of various malignancies. This streamlined and environmentally benign synthetic approach enables efficient access to pharmacologically relevant heterocycles with potential application in targeted cancer therapy.
Disclaimer: Curated by HT Syndication.
