MUMBAI, India, Aug. 12 -- Intellectual Property India has published a patent application (202641092049 A) filed by Dr. S J Shankar; Mrs. Akshatha R S; Dr. Kalyani Peluri; Mrs. Vidya Bharathi; Ms. Manasa C Reddy; Ms. Ranjitha Suresh; Ms. Thanushree H R; Ms. Kaviya G; and Ms. Ramali R on July 29, 2026, for Ethosomal Gel Composition For Enhanced Topical Management Of Diabetic Peripheral Neuropathy And A Process For Preparation Thereof.
Inventors include Dr. S J Shankar; Mrs. Akshatha R S; Dr. Kalyani Peluri; Mrs. Vidya Bharathi; Ms. Manasa C Reddy; Ms. Ranjitha Suresh; Ms. Thanushree H R; Ms. Kaviya G; and Ms. Ramali R.
The application for the patent was published on August 07, 2026, under issue no. 32/2026.
Abstract: ABSTRACT The present invention relates to a dual-active ethosomal gel composition for enhanced topical delivery of active ingredients useful in the management of diabetic peripheral neuropathy. The composition comprises alpha-lipoic acid, methylcobalamin, at least one phospholipid, ethanol, an aqueous phase, a membrane stabilizer, and a pharmaceutically acceptable gel-forming polymer. Alpha-lipoic acid is predominantly associated with the phospholipid bilayer, whereas methylcobalamin is incorporated within aqueous or interfacial regions of the ethosomal vesicles. The vesicles preferably have an average particle size of 80–350 nm, a polydispersity index not greater than 0.45, and sufficient surface charge or steric stabilization to resist aggregation. The ethosomal dispersion is incorporated into a skin- compatible gel matrix providing prolonged residence, controlled release, improved dermal penetration, and enhanced local retention of the active ingredients. The invention further provides a process comprising preparation of ethanolic and aqueous phases, controlled vesicle formation, size reduction by sonication or homogenization, and low-shear incorporation into the gel base. The composition is suitable for topical pharmaceutical manufacture and may provide antioxidant, neuroprotective, anti-inflammatory, and sensory-function-supporting effects while limiting systemic exposure
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