MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611106905 A) filed by Panipat Institute Of Engineering And Technology Piet on September 04, 2026, for Extended Release Matrix Tablet Composition Of Atorvastatin Calcium And Process For Preparation Thereof.
Inventors include Dr. Manisha; Dr. Sonia Narwal; and Dr. Gaurav Agarwal.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: [054] The present invention relates to an extended release matrix tablet composition of atorvastatin calcium and a process for preparation thereof. The composition comprises atorvastatin calcium, polyvinylpyrrolidone K-30 (PVP K-30) as a release-controlling polymer, starch, lactose, magnesium stearate, and talc. Representative 500 mg tablets contain 40 mg atorvastatin calcium and 20 mg, 40 mg, or 60 mg PVP K-30. The tablets are prepared by wet granulation using isopropyl alcohol, followed by drying, sizing, lubrication, and compression. In vitro dissolution in phosphate buffer at pH 6.8 showed cumulative drug release at 12 hours of 58.18%, 41.41%, and 32.54% for formulations containing 20 mg, 40 mg, and 60 mg PVP K-30, respectively. Kinetic evaluation supports substantially diffusion-controlled release from the matrix, while FT-IR analysis indicates compatibility between atorvastatin calcium and PVP K-30. The disclosed composition provides a simple formulation approach for controlling atorvastatin calcium release by varying PVP K-30 content. Accompanied Drawing [FIG. 1]
Disclaimer: Curated by HT Syndication.
