MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202611066734 A) filed by Mr. Tribhuwan Kumar Vashishtha; Ishan Ahmad; Alka Rani; Dr Mahesh Kumar Gupta; Dr. Nikhil Batra; Dr. Shikha Batra; Nayyar Parvez; Dr. Zafrul Hassan; Dr Kunjana Mittal; Akansha Bisht; and Mrs. Julekha Siddique on May 27, 2026, for Formulation Of Intranasal Nanoemulsions For Enhanced Brain Targeting In Alzheimer’s Diseas E.
Inventors include Mr. Tribhuwan Kumar Vashishtha; Ishan Ahmad; Alka Rani; Dr Mahesh Kumar Gupta; Dr. Nikhil Batra; Dr. Shikha Batra; Nayyar Parvez; Dr. Zafrul Hassan; Dr Kunjana Mittal; Akansha Bisht; and Mrs. Julekha Siddique.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: ABSTRACT TITLE: FORMULATION OF INTRANASAL NANOEMULSIONS FOR ENHANCED BRAIN TARGETING IN ALZHEIMER’S DISEASE The present invention discloses an intranasal nanoemulsion formulation for enhanced brain targeting in Alzheimer's disease comprising a lipid-based oil phase containing an active pharmaceutical ingredient, a surfactant-co-surfactant blend, an aqueous phase, a mucoadhesive polymer coating layer comprising chitosan, and an in situ gelling module comprising a thermosensitive poloxamer. The nanoemulsion globules have a mean diameter of 20 to 200 nanometers and exhibit a positive zeta potential ensuring mucoadhesion to nasal mucosa. Upon intranasal administration the formulation undergoes sol-to-gel transition at nasal temperature forming a sustained-release depot. The active ingredient is transported to the brain via olfactory and trigeminal nerve pathways bypassing the blood-brain barrier. The formulation achieves enhanced brain bioavailability, reduced systemic exposure, and is non-toxic to nasal tissue.
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