MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202647123444 A) filed by Fred Hutchinson Cancer Center on October 15, 2026, for Gene Editing For Latent Herpes Simplex Virus Infection Reduces Viral Load And Shedding In Vivo.
Inventors include Jerome, Keith; and Aubert, Martine.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: Embodiments of the present disclosure are directed to methods and compositions for treating recurrent Herpes simplex virus (HSV) disease associated with latent Herpes simplex virus type I(HSV-1) reactivation in a subject. In some embodiments, the composition comprises a plurality of at least three different adeno-associated viral vector (AAV) serotypes, each viral vector serotype comprising a first nucleic acid sequence encoding a first HSV-1-specific meganuclease, and a second nucleic acid sequence encoding a second HSV-1-specific meganuclease, separately. In some embodiments, the composition comprises an adeno-associated viral vector serotype comprising at least one sequence encoding an HSV-1-specific meganuclease targeting a duplicated region of the HSV-1 genome. In certain embodiments the adeno- associated viral vectors disclosed herein further comprise a neuron-specific promoter.
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