MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202621077840 A) filed by Lnct University on June 24, 2026, for Green Synthesized Metallic Nanoparticles Containing Lowsonia Inermis Leaf Extract (in Situ Gel) For Treatment Of Alzheimer Disease.
Inventors include Ms. Rajkumari Lodhi; and Dr. Virendra Kumar Sharma.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: [049] The present invention relates to a green synthesized metallic nanoparticle in situ gel composition comprising Lawsonia inermis leaf extract for neuroprotective delivery associated with Alzheimer’s disease. The leaf extract functions as a natural reducing, capping, stabilizing, and bioactive phytochemical source for preparing metallic nanoparticles under aqueous green synthesis conditions. The nanoparticles are incorporated into a physiologically responsive in situ gel matrix comprising gelling and mucoadhesive polymers. The composition remains flowable before administration and forms a gel under nasal physiological conditions, thereby increasing nasal residence time, reducing rapid clearance, and providing sustained release of phytochemical-capped metallic nanoparticles. The formulation supports brain-directed delivery through nasal mucosal pathways and may provide antioxidant, anti-inflammatory, and neuronal protective benefits relevant to Alzheimer’s disease-related neurodegeneration. The invention also provides a process for preparing the composition through leaf extraction, green nanoparticle synthesis, nanoparticle purification, gel base preparation, and incorporation of nanoparticles into the in situ gel matrix. Accompanied Drawing [FIGS. 1-2]
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