MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611112224 A) filed by Dr. Arun Kumar Mishra; Dr. Rekha Tarasingh Rajput; Lakshya Thakur; Digvijaya Saini; Dr. Agnimitra Dinda; Dr. Ankita Goyal; Dr. Abhishek Mathur; Dr. Sanjeev Kumar; Dr. Abhishek Pathak; and Ajay Dixit on September 18, 2026, for Herbal-Nutraceutical Composition Of Salacia Reticulata And Coscinium Fenestratum For Glycemic Management.
Inventors include Dr. Arun Kumar Mishra; Dr. Rekha Tarasingh Rajput; Lakshya Thakur; Digvijaya Saini; Dr. Agnimitra Dinda; Dr. Ankita Goyal; Dr. Abhishek Mathur; Dr. Sanjeev Kumar; Dr. Abhishek Pathak; and Ajay Dixit.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention discloses a herbal-nutraceutical composition comprising standardised hydroethanolic extracts of Salacia reticulata and Coscinium fenestratum combined at a weight ratio of 2:1 to 4:1 for synergistic glycaemic management. The Salacia reticulata extract, standardised to not less than 1 percent salacinol and 5 percent total polyphenols, inhibits intestinal alpha-glucosidase and alpha-amylase to suppress postprandial glucose absorption. The Coscinium fenestratum extract, standardised to not less than 8 percent berberine, activates AMPK-mediated glucose disposal and suppresses hepatic gluconeogenesis. The combination achieves synergistic interaction with a combination index of 0.62, reducing fasting blood glucose by 48 percent, glycosylated haemoglobin by 2.7 percentage points, and serum cholesterol by 32 percent in preclinical diabetic models. The composition demonstrates concurrent antioxidant protection and excellent safety with LD50 exceeding 2000 milligrams per kilogram. Formulated as oral capsules or tablets, it offers a safe, plant-derived alternative for pre-diabetic and type 2 diabetic individuals.
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