MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611112813 A) filed by Noida Institute Of Engineering And Technology Pharmacy Institute on September 21, 2026, for Hyaluronic Acid Hydrogel Of Curcumin, Propolis, And Green Tea Nanoparticles For Skin Cancer Chemoprevention.
Inventors include Dr. Saumya Das; and Dr. Avijit Mazumder.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to a nanoenabled hyaluronic acid-based topical hydrogel formulation comprising curcumin, standardised propolis extract, and standardised green tea extract co-encapsulated within poly(lactic-co-glycolic acid) nanoparticles of mean diameter 150-300 nanometres for chemoprevention and treatment of chemically induced skin carcinogenesis. The nanoparticles are prepared by nanoprecipitation with encapsulation efficiencies exceeding 70 percent for each phytochemical and dispersed within a 2 percent weight-by-volume hyaluronic acid matrix with polyvinyl alcohol, Tween 80, propylene glycol, glycerine, and paraben preservatives. The formulation exhibits skin-compatible pH, pseudoplastic shear-thinning rheology, sustained non-Fickian release, and CD44 receptor-mediated cutaneous uptake. In DMBA-croton oil induced Swiss albino mice, the formulation reduced tumor incidence to 40 percent, restored antioxidant enzyme activities to near-normal levels, and suppressed TNF-alpha and IL-6, with super
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