MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202411104795 A) filed by Amity University on December 31, 2024, for Innovative Silymarin-Embedded Nanostructured Lipid Carriers (nlcs) For Enhanced Transdermal Delivery: Design And Ex-Vivo Permeability Study.
Inventors include Narahari Narayan Palei; Amit Kumar Keshari; and Rahul Kushwaha.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: [0080] The present invention relates to a silymarin-embedded nanostructured lipid carrier (NLC) based transdermal drug delivery system and methods of preparation and use thereof. The nanostructured lipid carrier comprises a solid lipid, a liquid lipid, a surfactant, and a phospholipid, wherein silymarin is encapsulated within the lipid matrix in an amorphous or molecularly dispersed form. The NLCs are incorporated into a polymeric transdermal patch to facilitate enhanced skin permeation, controlled drug release, and improved bioavailability. The NLC-loaded transdermal patch demonstrates sustained release of silymarin and significantly enhanced ex vivo skin permeation compared to conventional silymarin patches. The invention provides a non-invasive and effective platform for transdermal delivery of poorly water-soluble therapeutic agents.
Disclaimer: Curated by HT Syndication.
