MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202641096184 A) filed by Vinayaka Missions Research Foundation, Vinayaka Missions Medical College on August 09, 2026, for Liposome-Encapsulated Surfactant Compositions For Targeted Antimicrobial Therapy Against Critical Priority Pathogens.
Inventors include Dr. K. Suganya; Dr. B. Jeyakumar; Dr. Ganesh Bala; Dr. Niranjjan R; and Dr. Sriram K..
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: A liposome-encapsulated surfactant composition for targeted antimicrobial therapy against critical priority pathogens is disclosed. A liposome encapsulates within its aqueous interior or bilayer a membrane-active surfactant antimicrobial agent, such as a polymyxin or cationic antimicrobial peptide, that kills bacteria by membrane disruption and retains activity against multidrug-resistant Gram-negative pathogens. The liposome is specifically constituted, by a bilayer-forming lipid together with a stabilizing component such as a sterol and a saturated high-transition-temperature phospholipid, to withstand the disruptive tendency of the membrane-active cargo and to retain it stably against premature leakage while retaining capacity to deliver it. A targeting moiety, binding a Gram-negative surface structure such as lipopolysaccharide or recognizing an infection-site condition, directs the liposome to the pathogen, whereupon it associates with or fuses with the bacterial membrane, delivering the surfactant at high local concentration to disrupt it, while a stealth coating prolongs circulation and host exposure is limited. The composition widens the therapeutic window, reducing the toxicity that limits free membrane-active antimicrobials. Preparation and treatment methods are disclosed.
Disclaimer: Curated by HT Syndication.
