MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202617072678 A) filed by Gene Company Pty Ltd. on June 11, 2026, for Low Immunogenic Exosome-Based Rna Package And Delivery System, Composition And Method Of Preparation Thereof.
Inventor includes Morris, Kevin.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: A low immunogenic exosome-based RNA package and delivery system capable of delivering a cargo RNA to a target site. In an embodiment, the low immunogenic exosome- based RNA package and delivery system comprises an exosome producing cell, one or more cargo RNA encoding plasmids and one or more fusion protein encoding plasmids, wherein the cargo RNA comprises a package RNA and a packaging domain and wherein the package fusion protein comprises an exosome associated transmembrane protein fused to a packaging protein. The present invention also provides an exosome composition comprising an exosome encapsulating a cargo RNA and a package fusion protein wherein the cargo RNA and the package fusion protein binds via the packaging domain and the packaging protein to form cargo RNA fusion protein complex. In an embodiment the packaging protein is endogenous to a subject. The present invention also provides a method of preparation of the exosome composition.
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