MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611107710 A) filed by Maharishi Markandeshwar Deemed To Be University on September 05, 2026, for Loxoprofen-Loaded Transferosomes-Based Patch For Transdermal Drug Delivery.
Inventors include Sukhbir Singh; Anjali; Neelam Sharma; and Sumeet Gupta.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention discloses a loxoprofen-loaded transferosomes-based transdermal patch for targeted and deep subcutaneous drug delivery. Developed using a thin- film hydration technique, the optimized transferosomes comprise loxoprofen, soy phosphatidylcholine, cholesterol, and span 40 as an edge activator, displaying an average vesicle size of 164.61 nm and a PDI of 0.261. The nanoformulation achieved a drug entrapment efficiency of 88.70% w/w and a process yield of 87.12% w/w. Transdermal patches fabricated by solvent evaporation using a PVA backing membrane and a PVP/ethyl cellulose polymeric matrix exhibited excellent physical integrity, folding endurance (312 ± 8 folds), and high drug content (97.58%). In-vitro release and ex-vivo pig skin permeation studies demonstrated 85.46% and 73.21% drug delivery at 24 hours, respectively, yielding a 2.54-fold enhancement over non-transferosomal patches. The patch effectively bypasses oral gastrointestinal side effects while ensuring sustained release.
Disclaimer: Curated by HT Syndication.
