MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202617097033 A) filed by Obi Pharma, Inc. on August 11, 2026, for Method For Antibody-Drug Conjugate Quality Improvement.
Inventors include Lai, Ming-Tain; Chou, Jun-Hong; Wang, Shy-Guey; Huang, Chen-Ping; Chou, Bing-Cheng; Lin, Hsiao-Han; and Chen, Ying-Shan.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: The present disclosure relates to a method for enhancing the quality (DAR distribution, stability and etc.) of glycosylated antibody-drug conjugates (ADCs) using active charcoal. In particular, the present disclosure adopts hydrophobic interaction chromatography (HIC) column, Protein A chromatography, active charcoal stirs and buffer exchange either alone or in tandem in order to exclude free glycosynthase enzymes. Therefore, the purity of glycosylated ADCs could be raised and ADC degradation could be prevented. Finally, the quality of OBI-902 (anti-TROP2 ADC) and OBI-904 (anti-Nectin-4 ADC) drug substance (DS) can be further determined.
Disclaimer: Curated by HT Syndication.
