MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202641123794 A) filed by Vellore Institute Of Technology on October 15, 2026, for Method For Assessing Triple-Negative Breast Cancer Using Eight-Gene Dna Methylation Panel.
Inventors include Devi Rajeswari V; and Sembiyaa A.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: ABSTRACT METHOD FOR ASSESSING TRIPLE-NEGATIVE BREAST CANCER USING EIGHT-GENE DNA METHYLATION PANEL An in vitro, computer- implemented method (100) for DNA methylation-based molecular assessment of triple-negative breast cancer (TNBC) is provided. DNA methylation measurements for an eight-gene panel (110) consisting of CCNA1, FGFR2, TGFB2, HDAC4, NOTCH1, DLL1, SMAD7, and TGFB3 are obtained from a biological sample (102) by DNA methylation profiling (104). The DNA methylation measurements are preprocessed and normalized (108) to obtain normalized DNA methylation measurements. A processor applies a predefined frozen scoring framework (112) to the normalized DNA methylation measurements corresponding to the eight genes to generate a composite DNA methylation biomarker score (114). The predefined frozen scoring framework has parameters fixed in advance on a reference DNA methylation dataset and is applied to the biological sample (102) without retraining. An output (124) based on the composite DNA methylation biomarker score (114) is provided for molecular assessment of the biological sample (102). (Fig. 1)
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