MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611112232 A) filed by Noida Institute Of Engineering And Technology Pharmacy Institute on September 18, 2026, for Mucoadhesive Orodispersible Mini-Tablets Of Metoprolol Tartrate With Taste-Masked Solid Lipid Microparticles.
Inventors include Dr. Rakhi Mishra; and Kavita Rana.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention discloses a mucoadhesive orodispersible mini-tablet composition of metoprolol tartrate for individualized low-dose cardiovascular therapy in paediatric, geriatric and dysphagic patients. Each mini-tablet is of three-millimetre diameter and twenty-milligram mass, containing one and one-quarter milligrams of metoprolol tartrate encapsulated within spray-congealed glyceryl behenate solid lipid microparticles of eighty to one hundred twenty micrometre diameter, dispersed in a co-processed mannitol-crospovidone-silicified microcrystalline cellulose superdisintegrant matrix, and overcoated with an in-situ chitosan-sodium alginate polyelectrolyte complex. The composition exhibits oral disintegration within seventeen seconds, taste-masking efficiency of ninety-two percent, mucoadhesive buccal residence above one hundred seconds, immediate gastric drug release above eighty-five percent within fifteen minutes, and content uniformity acceptance value of four and two-tenths. A colour-coded multi-cavity blister enables caregiver dose titration in one and one-quarter milligram increments up to twenty-five milligrams without tablet splitting.
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