MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202511123702 A) filed by Indian Institute Of Technology Kanpur on December 08, 2025, for Nanoparticulate Formulation Of Remdesivir And Doxorubicin And Method Of Preparing The Same.
Inventors include Katti, Dhirendra S.; Bose, Adrija; and Zaidi, Zahra Sifat.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present disclosure relates to multi-agent pharmaceutical compositions comprising Remdesivir in combination with chemotherapeutic small molecules such as Doxorubicin, and to nanoparticle-based systems for their delivery. The composition employs carboxylated chitosan–coated mesoporous silica nanoparticles (COOH- Chi-MSNs) that enable high loading capacity, improved stability, and pH-responsive release of the incorporated agents. The disclosure further provides processes for preparing single-drug loaded nanoformulation of both Remdesivir and Doxorubicin which show synergistic effects in sequential combination in preclinical studies. The method of preparation of the nanoformulations include the steps of nanoparticle synthesis, polymer coating, drug encapsulation, purification, and characterization. The disclosed nanoformulations exhibit , controlled release behaviour, and tunable drug ratios arising from the structural and functional features of the engineered nanocarrier platform. The compositions and processes described herein offer a scalable and versatile platform for the development of synergistic multi-drug pharmaceutical products.
Disclaimer: Curated by HT Syndication.
