MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202621108884 A) filed by Dr. Vishwanath Karad Mit World Peace University on September 10, 2026, for Novel Pyrazolo[3,4-D] Pyrimidine Derivatives And Processes For Preparation Thereof.
Inventors include Ranjit Vinaykrao Gadhave; Ganesh Bhaurao Choudhari; Shweta Dilip Raut; Hriday Ramkrishna Shetty; and Saurabh Priyadarshi.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: ABSTRACT NOVEL PYRAZOLO[3,4-D] PYRIMIDINE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF The present invention relates to novel pyrazolo[3,4-d]pyrimidine derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers and polymorphic forms thereof, useful as Heat Shock Protein 90 (HSP90) inhibitors. The compounds comprise substituted pyrazolo[3,4- d]pyrimidine scaffolds bearing substituted benzamide moieties, wherein the substituents enhance binding affinity toward the N-terminal ATP-binding domain of HSP90 and provide potential anticancer activity. The invention further provides processes for preparing the compounds of Formula (I), comprising reacting an arylhydrazine with ethoxymethylenemalononitrile to obtain an aminopyrazole intermediate, cyclizing the intermediate with formamide to obtain a pyrazolo[3,4- d]pyrimidine intermediate, and coupling the intermediate with a substituted benzoyl chloride or activated substituted benzoic acid in the presence of a coupling reagent and an organic base. The compounds exhibit favorable physicochemical and biological properties and are useful for treating or preventing HSP90-mediated disorders, including cancer.
Disclaimer: Curated by HT Syndication.
