Intellectual Property India Publishes Patent Application for Novel Schiff Base Deriva Ves As Potent Anmicrobial Agents: Synthesis And In Silico Molecular Docking Analysis On Cytochrome P450 Enzyme"

MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202621059176 A) filed by Prachi Pradip Khobragade; Dr. Atul Nagpure; Samiksha Borghare; Dr. Jay Tanna; Spurti Dekate; Dimpal Maindalkar; and Prof. Rajendra S. Dongre on May 09, 2026, for Novel Schiff Base Deriva Ves As Potent Anmicrobial Agents: Synthesis And In Silico Molecular Docking Analysis On Cytochrome P450 Enzyme".

Inventors include Prachi Pradip Khobragade; Dr. Atul Nagpure; Samiksha Borghare; Dr. Jay Tanna; Spurti Dekate; Dimpal Maindalkar; and Prof. Rajendra S. Dongre.

The application for the patent was published on July 10, 2026, under issue no. 28/2026.

Abstract: The present invention relates to the synthesis and characterization of novel Schiff base compounds derived from the condensation of aromatic aldehydes and primary amines, and their application as potent antimicrobial agents. The synthesized Schiff base derivatives were evaluated for their antibacterial and antifungal activities against a panel of clinically significant pathogenic microorganisms including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans using the agar disc diffusion and minimum inhibitory concentration (MIC) methods. The synthesized compounds demonstrated significant broad-spectrum antimicrobial activity, with MIC values ranging from 4 to 64 µg/mL against tested organisms. Molecular docking studies were performed against the Cytochrome P450 (CYP450) enzyme — a key target in antimicrobial and drug metabolism pathways — using AutoDock Vina software. Docking analysis revealed favourable binding interactions, including hydrogen bonding and hydrophobic contacts, with binding energy values ranging from -6.5 to -9.2 kcal/mol, indicating strong affinity toward the active site of the target protein. Structural characterization of the synthesized compounds was achieved through UV-Visible spectroscopy, FT-IR, 1H NMR, 13C NMR, and mass spectrometry. The present invention discloses novel Schiff base structures, their synthesis methodology, biological evaluation data, and computational docking profiles that collectively establish the utility of these compounds as promising candidates for antimicrobial drug development.

Disclaimer: Curated by HT Syndication.