MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202647082158 A) filed by Dr. Reddy'S Institute Of Life Sciences on July 03, 2026, for Nucleic Acid Sequence(s) And Construct(s) For Treating Methylmalonic Acidemia And Method(s) Thereof.
Inventors include Sevilimedu, Aarti; Rani, Rita; Parsa, Kishore; Chatti, Kiranam; and Oruganti, Srinivas.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: The present disclosure provides a nucleic acid sequence encoding MMUT for the treatment of Methylmalonic acidemia (MMA). Said nucleic acid is codon optimized to improve various parameters and allows high expression in the cells it is expressed in. The present disclosure also provides nucleic acid construct(s) comprising the nucleic acid sequence encoding MMUT along with one or more regulatory elements. Modes of delivery of the said nucleic acid sequence include delivery by way of encapsulation in a lipid nanoparticle when the nucleic acid is an mRNA and by way of a recombinant AAV vector when the nucleic acid is a DNA sequence. The present disclosure also relates to a composition and kit comprising the nucleic acid sequence, constructs or delivery vehicles as well as their applications in treating MMA.
Disclaimer: Curated by HT Syndication.
