MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202621062454 A) filed by Dr. Ratnnadeep C. Sawant on May 17, 2026, for One-Pot Synthesis Of First-Line Anti-Tubercular Agents.
Inventors include Dr. Ratnnadeep C. Sawant; Ms. Anisha C. Rokade; Mr. Harshal D. Nakade; Ms. Renuka P. Bakde; Dr. Rahul B. Kamble; and Dr. Yeshwant R. Bhorge.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: ABSTRACT OF THE INVENTION: The present invention relates to a novel, efficient, and environmentally benign one-pot synthesis protocol for the production of first-line anti-tubercular agents, including Isoniazid, Pyrazinamide, and related derivatives suitable for Ethambutol and Rifampicin integration. The method enables sequential reactions—activation, condensation, hydrazinolysis, and functionalization—within a single reaction vessel using green solvents and catalysts, significantly reducing processing time, solvent consumption, and waste generation compared to conventional multi-step syntheses. Key advantages include high atom economy (75- 95% yields), operational simplicity, scalability, and compatibility with fixed-dose combination manufacturing. The process minimizes intermediate isolation, employs mild conditions, and produces compounds with retained potent activity against Mycobacterium tuberculosis (including drug-sensitive strains). Detailed reaction parameters, catalysts (e.g., ionic liquids, solid acids), and workup procedures are optimized for industrial applicability. This invention overcomes limitations of prior art by providing a unified cascade approach that lowers production costs, enhances sustainability, and facilitates greater access to essential TB medications in resource- limited settings. Supporting data from case studies, yield comparisons, and biological assays validate the superiority of the disclosed methodology. The invention encompasses the process, intermediates, compositions, and uses thereof.
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