MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611113066 A) filed by Dr. Nupur Bhatnagar; Dr. Pawan Kumar Katariya; Dr. Megha Sharma; Dr. Sanju Jainth; Ms. Urmila Verma; and Dr. Divaker Shukla on September 21, 2026, for Ph-Triggered Nano-Encapsulation Systems For Targeted Antimicrobial Delivery In Chronic Wounds..
Inventors include Dr. Nupur Bhatnagar; Dr. Pawan Kumar Katariya; Dr. Megha Sharma; Dr. Sanju Jainth; Ms. Urmila Verma; and Dr. Divaker Shukla.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to a pH-triggered nano-encapsulation system comprising biocompatible polymeric nanoparticles loaded with an antimicrobial agent for targeted delivery in chronic wounds. The nanoparticles, prepared by ionic gelation of chitosan with sodium tripolyphosphate, exhibit a mean particle size of 182.6 nanometres, encapsulation efficiency of 86.4 percent, positive zeta potential, and pH-responsive release behaviour releasing 94.2 percent of the encapsulated antimicrobial at pH 5.5 compared with 73.6 percent at pH 7.4 within 24 hours. The formulation produces zones of inhibition of 25.8, 23.6, and 24.7 millimetres against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli respectively, representing 39 to 44 percent enhancement over the free antimicrobial agent. The system provides site-specific, on-demand antimicrobial delivery exploiting the acidic pH of infected chronic wounds, with demonstrated biofilm penetration and eradication capability, offering a promising corticosteroid-free therapeutic platform for chronic wound management.
Disclaimer: Curated by HT Syndication.
