MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202621084924 A) filed by Parul Institute Of Ayurved, Parul University on July 10, 2026, for Polyherbal Injectable Formulation With Detoxified Aconitum Ferox For Local Anesthesia.
Inventors include Dr. Hemant Toshikhne; Dr. Parikshit Shirode; Dr. Bijal Prajapati; Dr. Anitha H.; and Dr. Harsh Ramabhai Patel.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: A polyherbal injectable formulation for local anesthesia comprises standardized hydro-alcoholic extracts of detoxified Aconitum ferox, Anacyclus pyrethrum, and Myristica fragrans in a 2:1:1 weight ratio, formulated in a sterile isotonic aqueous vehicle. Aconitum ferox undergoes Ayurvedic Shodhana detoxification using cow's urine and cow's milk at 90–95°C for approximately 3 hours, converting toxic aconitine alkaloids into safer derivatives while preserving anesthetic activity. Each herb is extracted separately via hydro-alcoholic Soxhlet extraction (ethanol:water 50:50 v/v) for 7 cycles. The combined extracts are processed by homogenization (5000–6000 rpm, 5–15 minutes) and ultrasonication (2 minutes), producing a stable nano-dispersion with 100–150 nm particle size, polydispersity index below 0.3, and zeta potential approximately –22 mV. The formulation is sterile-filtered (0.22 µm), pH-adjusted (6.8–7.2), and aseptically filled into Type-I borosilicate glass ampoules. In vivo evaluation demonstrates dose-dependent reversible peripheral nerve conduction blockade with efficacy comparable to 2% lignocaine, approximately 60-minute anesthetic duration, NOAEL exceeding 10 mg/mL, and pharmaceutical stability for at least six months under ICH storage conditions.
Disclaimer: Curated by HT Syndication.
