MUMBAI, India, July 31 -- Intellectual Property India has published a patent application (202411095679 A) filed by Indian Council Of Medical Research on December 04, 2024, for Producing A Chimeric Recombinant Multi-Stage Vaccine For Preventing Plasmodium Falciparum Infection And Its Community Transmission.
Inventors include Dr. Singh, Susheel Kumar; Dr. Singh, Subhash; Dr. Singh, Agam Prasad; and Dr. Pati, Sanghamitra.
The application for the patent was published on July 24, 2026, under issue no. 30/2026.
Abstract: The present disclosure relates to a method for expression and purification of a chimeric immunogenic polypeptide comprising a full-length Circumsporozoite protein (PfflCSP) and transmission blocking antigens (PfsPro6C) selected from Pro-subdomain of protein Pfs230 and 6C-subdomain of protein Pfs48/45 of Plasmodium falciparum. The present disclosure also describes a recombinant vaccine (flPfCSP-PfsPro6C) composition against P. falciparum parasites expressed and purified protein from Lactococcus lactis and a pharmaceutically acceptable carrier or adjuvant for protection against infection in humans as well as reducing the community transmission.
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