MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202411103980 A) filed by Lovely Professional University on December 28, 2024, for Quality By Design Development Of Snedds For Fisetin And Hesperidin Bioavailability.
Inventors include Dr. Rajan Kumar; and Dr. Sachin Kumar Singh.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: The present invention relates to a Self-Nanoemulsifying Drug Delivery System (SNEDDS) designed to enhance the bioavailability of fisetin and hesperidin, which are active pharmaceutical ingredients (APIs). The SNEDDS comprises a combination of oils, including medium-chain triglycerides, to form an oil phase that solubilizes the APIs, along with surfactants such as Tween 80 to reduce interfacial tension, and co-surfactants like polyethylene glycol to stabilize the nanoemulsion. Upon contact with aqueous media, the SNEDDS spontaneously forms an oil-in-water nanoemulsion with a particle size of less than 200 nm. Developed using a Quality by Design (QbD) approach, the system optimizes critical quality attributes (CQAs) such as particle size, drug release, stability, and bioavailability. The invention also includes a method for preparing the SNEDDS, involving solubilization of the APIs, mixing of surfactants and co-surfactants, and high-shear mixing to form a nanoemulsion, which is further evaluated for CQAs.
Disclaimer: Curated by HT Syndication.
