MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202611080015 A) filed by Noida Institute Of Engineering And Technology Niet on June 29, 2026, for Quercetin-Loaded Cerium Oxide Nanozyme–silica Nanocomposite Enhances Intestinal Epithelial Cytoprotection Against Oxidative Stress.
Inventors include Annu Bhati; and Ashish Joshi.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: The present invention provides a cerium oxide nanozyme-coated mesoporous silica nanocomposite loaded with quercetin (CeO2-MSN/Q) and a process for its preparation. The nanocomposite comprises an MCM-41 type mesoporous silica core, a cerium oxide nanozyme coating chemically anchored on the external surface exhibiting superoxide dismutase and catalase mimetic activities through a self-regenerating Ce3+/Ce4+ redox cycle, and quercetin loaded within the mesoporous channels. The nanocomposite exhibits synergistic dual-mechanism antioxidant activity combining catalytic enzymatic ROS scavenging by the cerium oxide coating and chemical ROS scavenging by the loaded quercetin. In Caco-2 intestinal epithelial cells subjected to H2O2-induced oxidative stress, the nanocomposite achieves relative viability recovery exceeding 100 percent at quercetin-equivalent concentrations of 100 micromolar, significantly superior to free quercetin or uncoated MSN/Q. The nanocomposite is non-cytotoxic and eliminates the need for organic
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