MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202641058001 A) filed by Saveetha Institute Of Medical And Technical Sciences on May 07, 2026, for Synthesis And Biological Evaluation Of Novel Pyridine-4-Carboxaldehyde Derivatives As Antimicrobial.
Inventors include Malathi. V; T. Selvankumar; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: The present invention discloses a novel synthetic methodology for the preparation, characterization, and biological evaluation of Schiff base compounds derived from the condensation of pyridine-4-carboxaldehyde with amine derivatives in the presence of methanol as the reaction medium. The synthesis is conducted under controlled thermal conditions at 50°C, wherein the amine component is introduced to the pre-formed aldehyde solution and subjected to continuous stirring for three hours at the same temperature. Following completion of the reaction, the solvent is allowed to evaporate, and the resulting Schiff base product demonstrates ambient stability for a minimum period of one week under standard room temperature storage conditions. The synthesized compounds are comprehensively characterized through an integrated suite of spectroscopic techniques, including infrared spectroscopy, nuclear magnetic resonance, UV-visible spectroscopy, and mass spectrometry, complemented by computational approaches encompassing molecular docking simulations, density functional theory calculations, and ADMET profiling to elucidate structural integrity and predict pharmacological behavior at the molecular level. Antimicrobial activity of the synthesized compounds is assessed using a standardized well-plate diffusion assay, wherein test solutions prepared in dimethyl sulfoxide are evaluated against both bacterial and fungal microorganisms under organism-specific incubation conditions of 37°C for 18-24 hours and 25-30°C for 48 hours, respectively. Antimicrobial potency is quantified by measuring zones of inhibition in millimeters and benchmarked against validated positive and negative controls. The described invention offers significant industrial applicability in pharmaceutical research, providing a reproducible, scalable, and structurally diversifiable platform for the systematic discovery of novel antimicrobial and antifungal therapeutic agents.
Disclaimer: Curated by HT Syndication.
