Intellectual Property India Publishes Patent Application for Synthesis Of Schiff Bases Of Dihydropyrimidinethione Derivatives Using Indole -3-Carboxaldehyde And Its Anti-Prostate Cancer Activity.

MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202441100702 A) filed by Shamna Z; Greeshma S; Nazrin Fathima A; N L Gowrishankar; and Sumathy A on December 19, 2024, for Synthesis Of Schiff Bases Of Dihydropyrimidinethione Derivatives Using Indole -3-Carboxaldehyde And Its Anti-Prostate Cancer Activity..

Inventors include Shamna Z; Greeshma S; Nazrin Fathima A; N L Gowrishankar; and Sumathy A.

The application for the patent was published on June 26, 2026, under issue no. 26/2026.

Abstract: Background & Objective: Prostate cancer is the common type of cancer seen in male and second leading cause of death. The inefficacy and resistant to antiandrogen drugs emphasize the need of new drug molecule with low adverse effects. The current research study is to perform the Insilco studies, synthesize newer schiff bases of dihydropyrimidine thiones using Indole-3-carboxaldehyde by adopting biginelli condensation reaction and to characterize the synthesized compounds by spectral methods. Materials & Methods: The design of Schiff bases of dihydropyrimidine thione derivatives (D series) was done by Chemsketch. The Insilco studies was performed on all designed compounds. The ADME studies was performed on Swiss ADME & Toxicity Studies on OSIRIS toxicity explorer. The Molecular docking was done on Autodock vina integrated via PyRx 8.0. The synthesis was done by adopting Biginelli condensation reaction. The synthesis compounds elucidated using spectral methods (IR, NMR, MASS) and the anticancer activity was studied on PC-3 cell lines. Results & Discussion: 70 compounds (B, C & D series) were screened and the best fit derivatives are synthesized and evaluated for its antiprostate activity. The compound DP-3 showed significant antiprostate activity (10.92 ± 0.41). Conclusion : The synthetic approach for the synthesis of schiff bases of dihydropyrimidine thione derivatives using Indole-3-carboxaldehyde is simple & efficient which yields good result. And compounds have remarkable antioxidant activity and antiprostate activity against androgen receptor. Keywords: Prostate Cancer; Dihydropyrimidine thiones; Indole-3-carboxaldehyde; Biginelli reaction Insilco studies; Schiff bases.

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