MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202617069475 A) filed by Treeline Biosciences, Inc. on June 03, 2026, for Tetrahydroisoquinoline Heterobifunctional Bcl-Xl Degraders.
Inventors include Horn, Evan J.; Hansen, Joshua D.; Alexander, Matthew D.; Huang, Fei Number; Nagy, Mark A.; and Zahara, Adam Jamil.
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: This disclosure provides compounds of Formula (I) (e.g., Formula (I-1) (e.g., Formula (I-a1), (I-a3), (I-b1), (I-bb1), (I-d1), (I-dd1), (I- e1), (I-e1-a), (I-f1), (I-g1), (I-b3), (I-c3), (I-d3), or (I-e3)), Formula (I-2) (e.g., Formula (I-a2), (I-a4), (I-b2), (I-c2), (I-d2), (I-e2), (I- b4), (I-c4), or (I-e4)), Formula (I-5) (e.g., (I-a5), (I-b5), or (I-e5)), Formula (I-6) (e.g., (I-a6), (I-b6), or (I-c6)), Formula (II-1), or Formula (II-2)) or Formula (A), or a pharmaceutically acceptable salt thereof, that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions comprising the compounds, or pharmaceutically acceptable salts thereof, provided herein as well as methods of using and making the same.
Disclaimer: Curated by HT Syndication.
