MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202641080072 A) filed by Dumala Naresh; Prasada Chowdari Gurram; and Koneru Lakshmaiah Education Foundation Klef on June 29, 2026, for Thermosensitive Intranasal In Situ Gel Composition Of Avanafil For Nose- To-Brain Delivery.
Inventors include Ms. Radha Kasaraneni; Dr. Prasada Chowdari Gurram; Dr. Thummala Udaya Kumar; Dr. Chirnaj Vasanthi; Ms. Jahasultana Mohammed; Dr. Sairaj Satarkar; Dr. Ajmal Nassar; Dr. A Narayana Rao; Ms. Dimple Mohan Kundla; and Dr. Chakravarthi Guntupalli.
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: The present disclosure relates to a thermosensitive mucoadhesive intranasal in situ gel composition comprising Avanafil and a process for preparation thereof. The composition comprises Avanafil, Poloxamer 407, Poloxamer 188, hydroxypropyl methylcellulose (HPMC K4M), polyethylene glycol 400 (PEG 400), benzalkonium chloride, sodium chloride, and pharmaceutically acceptable excipients. The process comprises preparation of a thermoreversible polymeric solution by the cold method, incorporation of Avanafil into the polymer matrix, addition of mucoadhesive and auxiliary agents, and formation of a stable in situ gel formulation suitable for intranasal administration. The composition exhibits appropriate gelation temperature, rapid sol-to-gel transition at physiological nasal temperature, satisfactory mucoadhesive properties, and sustained drug release characteristics. Characterization studies including Fourier Transform Infrared Spectroscopy (FTIR), physicochemical evaluation, viscosity analysis, gelation studies, drug content determination, and ex vivo nasal permeation studies demonstrate compatibility among formulation components and suitability of the formulation for intranasal delivery. The disclosed composition and process provide a stable thermosensitive mucoadhesive intranasal in situ gel formulation of Avanafil with potential utility for enhanced nasal drug delivery and brain-targeting applications.
Disclaimer: Curated by HT Syndication.
