MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202411103977 A) filed by Lovely Professional University on December 28, 2024, for Thiochromene Amino-Acid Conjugates As Inhibitors Of Leishmanial N-Myristoyl Transferase.
Inventor includes Banoth Karan Kumar.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: The present invention relates to the field of medicinal chemistry, specifically to novel compounds designed as inhibitors of leishmanial N-myristoyltransferase, an enzyme critical for the survival of Leishmania parasites. The invention comprises thiochromene amino-acid conjugates, where a thiochromene moiety forms the core structure conjugated with an aromatic amino acid. The thiochromene moiety is substituted with electron-withdrawing or electron-donating groups, enhancing the compound's binding affinity and specificity towards the N-myristoyltransferase enzyme. These compounds are configured to disrupt protein-protein interactions and ribosylation processes essential for parasite survival. The invention also includes methods for synthesizing these conjugates, evaluating their binding affinity through in- silico studies, and assessing their anti-leishmanial activity through biological assays.
Disclaimer: Curated by HT Syndication.
