MUMBAI, India, June 24 -- Intellectual Property India has published a patent application (202617062537 A) filed by Tacit Therapeutics, Inc. on May 18, 2026, for Trans-Splicing Nucleic Acid Molecules And Methods Of Use.
Inventor includes Nelles, David Allen.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: The present disclosure provides compositions, systems, and methods for promoting trans-splicing. In some examples, provided herein is a composition comprising or encoding a trans-splicing nucleic acid molecule comprising a 3' domain disclosed herein. In some embodiments, the 3' domain comprises one or more of the following domains: a nuclear retention domain, a stabilization domain, and a cleavage domain. In some embodiments, the 3' domain comprises a sequence or structure that functions as any one, any two, or all three of a nuclear retention domain, a stabilization domain, and a cleavage domain. In some embodiments, the 3' domain comprises: (i) a sequence or structure derived or isolated from a ribozyme (e.g., Twister or Twister Sister), and (ii) optionally a structured sequence or domain (e.g., a G-quadruplex, a pseudoknot, and/or a triplex), in the 3' to 5' direction.
Disclaimer: Curated by HT Syndication.
